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The unprocessed data thus obtained were su … The unprocessed data thus obtained were successively imported to MATLAB7.0.4 (Mathworks, http://www.mathworks.com/). All alignments and metabolite identification were performed as described by Kusano et al. (2007a).<br />
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All statistical tests for metabolite profiling and metabolite-to-metabolite correlation analysis were performed as described by Kusano et al. (2007a). We confirmed that the correlations from -1.0 to 1.0 followed Gaussian distribution. The false-discovery rate method of Benjamini and Hochberg (1995) was used to correct for multiple testing. All statistical tests were performed using the R statistical software (http://www.r-project.org/). The differential metabolite-correlation analyses and the corresponding statistical tests are described in Method S1. tistical tests are described in Method S1.
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