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| SE53:/ |
| SE Authors | Miyako Kusano, Henning Redestig, Tadayoshi Hirai, Akira Oikawa, Fumio Matsuda, Atsushi Fukushima, Masanori Arita, Shin Watanabe, Megumu Yano, Kyoko Hiwasa-Tanase, Hiroshi Ezura, Kazuki Saito |
|---|---|
| SE Description | We propose using multiple analytical platf … We propose using multiple analytical platforms for the direct acquisition of an interpretable data set of estimable chemical diversity. As an example, we report an application of our multi-platform approach that assesses the substantial equivalence of tomatoes over-expressing the taste-modifying protein miraculin. In combination, the chosen platforms detected compounds that represent 86% of the estimated chemical diversity of the metabolites listed in the LycoCyc database. Following a proof-of-safety approach, we show that w92% had an acceptable range of variation while simultaneously indicating a reproducible transformation-related metabolic signature. We conclude that multi-platform metabolomics is an approach that is both sensitive and robust and that it constitutes a good starting point for characterizing genetically modified organisms. acterizing genetically modified organisms. |
| SE ID | SE53 + |
| SE Reference | Kusano M et al. (2011) PLOS ONE 6: e16989 |
| SE Title | Covering chemical diversity of genetically-modified tomatoes using metabolomics for objective substantial equivalence assessment + |
| Modification dateThis property is a special property in this wiki. | 18 April 2018 01:58:14 + |
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